Life-long oligodendrocyte development and plasticity
نویسندگان
چکیده
منابع مشابه
Oligodendrocyte Development and Plasticity.
Oligodendrocyte precursor cells (OPCs) originate in the ventricular zones (VZs) of the brain and spinal cord and migrate throughout the developing central nervous system (CNS) before differentiating into myelinating oligodendrocytes (OLs). It is not known whether OPCs or OLs from different parts of the VZ are functionally distinct. OPCs persist in the postnatal CNS, where they continue to divid...
متن کاملPlasticity in the adult human oligodendrocyte lineage.
Preoligodendrocytes have been described in cultures and tissue prints of adult human white matter (Armstrong et al., 1992). To characterize further these precursors of human oligodendrocytes, we have investigated whether they express genes playing a critical role in oligodendrocyte development. In the intact human brain, platelet-derived growth factor receptor alpha (PDGF alpha R) and myelin tr...
متن کاملEndothelin-1 regulates oligodendrocyte development.
In the postnatal brain, oligodendrocyte progenitor cells (OPCs) arise from the subventricular zone (SVZ) and migrate into the developing white matter, where they differentiate into oligodendrocytes and myelinate axons. The mechanisms regulating OPC migration and differentiation are not fully defined. The present study demonstrates that endothelin-1 (ET-1) is an astrocyte-derived signal that reg...
متن کاملAxonal Control of Oligodendrocyte Development
1. Abbreviations used in this paper: BrdU, bromodeoxyuridine; OPCs, oligodendrocyte precursor cells; TTX, tetrodotoxin. H OW are the numbers of different cell types matched together during tissue development? The nervous system has provided an excellent model system for understanding this question as it contains two main classes of cell types, neurons and glia. Presynaptic neurons are believed ...
متن کاملCells and signaling in oligodendrocyte development.
The myelin-synthesizing oligodendrocyte is compromised in many neuropathological diseases, including demyelinating diseases (e.g. multiple sclerosis), metabolic diseases (e.g. Pelizaeus-Merzbacher), infectious diseases (e.g. progressive multifocal leukoencephalopathy), neurodegenerative diseases (e.g. multisystem degeneration), and possibly neoplasms (e.g. oligodendrogliomas). Understanding the...
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ژورنال
عنوان ژورنال: Seminars in Cell & Developmental Biology
سال: 2021
ISSN: 1084-9521
DOI: 10.1016/j.semcdb.2021.02.004